The beginning of Season 2 reveals Colin's fate. The entire town blames Andy for "killing" Colin. They stop going to his practice and shun his children.

Andy stands by his decision and eventually admits to Ephram that he could have saved Colin's life, but he would have been severely disabled, both mentally and physically, and at Colin's insistence, he had promised Colin that he would not let him live that way.

Amy struggles with the death of Colin and falls into a deep depression, eventually going on medication and meeting Tommy, a drug-dealing boy who would come to be more than a friend. She considers sleeping with Tommy, but backs out of it every time he brings it up.

Harold buys her a new car to try and cheer her up, but Amy continues to act out and fail in school. Rose tells Harold that he is babying her and she is unwelcome in her house until she follows the rules, which forces Amy to move in with her grandmother, Edna. Amy's downward spiral continues until Tommy takes her to a wild party.

He gives her a bottle of water laced with GHB. Already intoxicated, Amy drinks it, then has a hallucination of Colin, telling her to let him go and get on with her life. The vision shocks her back to reality and she realizes that Tommy has drunk most of the water himself and subsequently overdosed.

Amy does the only thing she can think of and calls her father for help. Tommy recovers, but Amy is officially scared straight. She dumps him, moves back in with her parents, and begins to improve her behavior and mood.